Pepsin-catalysed addition of water to a ketomethylene peptide isostere: observation of the tetrahedral species by 13C-nuclear-magnetic-resonance spectroscopy

HOLLADAY, MARK W.; SALITURO, FRANCESCO G.; SCHMIDT, PAUL G.; RICH, DANIEL H.

doi:10.1042/bst0131046

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Conference Article| December 01 1985

Pepsin-catalysed addition of water to a ketomethylene peptide isostere: observation of the tetrahedral species by ¹³C-nuclear-magnetic-resonance spectroscopy

MARK W. HOLLADAY;

MARK W. HOLLADAY

*School of Pharmacy, University of Wisconsin — Madison, 425 N. Charter St., Madison, WI 53706, U.S.A.

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FRANCESCO G. SALITURO;

FRANCESCO G. SALITURO

*School of Pharmacy, University of Wisconsin — Madison, 425 N. Charter St., Madison, WI 53706, U.S.A.

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PAUL G. SCHMIDT;

PAUL G. SCHMIDT

†Vestar Research Inc., 939 East Walnut St., Pasadena, CA 91106, U.S.A.

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DANIEL H. RICH

DANIEL H. RICH ‡

*School of Pharmacy, University of Wisconsin — Madison, 425 N. Charter St., Madison, WI 53706, U.S.A.

‡To whom correspondence should be addressed

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Author and article information

Publisher: Portland Press Ltd

Online ISSN: 1470-8752

Print ISSN: 0300-5127

1985

Biochem Soc Trans (1985) 13 (6): 1046–1048.

https://doi.org/10.1042/bst0131046

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Pepsin-catalysed addition of water to a ketomethylene peptide isostere: observation of the tetrahedral species by ¹³C-nuclear-magnetic-resonance spectroscopy