Effect of Carboxyl Group Esterification of Methotrexate on its Properties as an Inhibitor of Dihydrofolate Reductase and a Substrate for Aldehyde Oxidase

JOHNS, DAVID G.; FARQUHAR, DAVID; CHABNER, BRUCE A.; McCORMACK, JOHN J.

doi:10.1042/bst0020602

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Conference Article| August 01 1974

Effect of Carboxyl Group Esterification of Methotrexate on its Properties as an Inhibitor of Dihydrofolate Reductase and a Substrate for Aldehyde Oxidase

DAVID G. JOHNS;

DAVID G. JOHNS

*National Cancer Institute, National Institutes of Health, Bethesda, Md. 20014, U.S.A.

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DAVID FARQUHAR;

DAVID FARQUHAR

^†Developmental Therapeutics, The University of Texas M.D. Anderson Hospital and Tumour Institute, Houston, Tex. 77025, U.S.A.

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BRUCE A. CHABNER;

BRUCE A. CHABNER

*National Cancer Institute, National Institutes of Health, Bethesda, Md. 20014, U.S.A.

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JOHN J. McCORMACK

^‡Department of Pharmacology, University of Vermont College of Medicine, Burlington, Vt. 05401, U.S.A.

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Author and article information

Publisher: Portland Press Ltd

Online ISSN: 1470-8752

Print ISSN: 0300-5127

1974

Biochem Soc Trans (1974) 2 (4): 602–604.

https://doi.org/10.1042/bst0020602

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