Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: ‘designer’ changes in Vmax, stability and membrane association

Houslay, M. D.; Scotland, G.; Pooley, L.; Spence, S.; Wilkinson, I.; McCallum, F.; Julien, P.; Rena, N. G.; Michie, A. M.; Erdogan, S.; Zeng, L.; O'Connell, J. C.; Tobias, E. S.; MacPhee, I.

doi:10.1042/bst0230393

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Conference Article| May 01 1995

Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: ‘designer’ changes in V_max, stability and membrane association

M. D. Houslay;

M. D. Houslay

1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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G. Scotland;

G. Scotland

1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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L. Pooley;

L. Pooley

1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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S. Spence;

S. Spence

1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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I. Wilkinson;

I. Wilkinson

1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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F. McCallum;

F. McCallum

1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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P. Julien;

P. Julien

1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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N. G. Rena;

N. G. Rena

1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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A. M. Michie;

A. M. Michie

1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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S. Erdogan;

S. Erdogan

1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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L. Zeng;

L. Zeng

1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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J. C. O'Connell;

J. C. O'Connell

1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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E. S. Tobias;

E. S. Tobias

1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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I. MacPhee

1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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Author and article information

Publisher: Portland Press Ltd

Received: January 10 1995

Online ISSN: 1470-8752

Print ISSN: 0300-5127

1995

Biochem Soc Trans (1995) 23 (2): 393–398.

https://doi.org/10.1042/bst0230393

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Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: ‘designer’ changes in V_max, stability and membrane association

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Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: ‘designer’ changes in V_max, stability and membrane association