A subset of stem-like cells from bone marrow that are referred to as marrow stromal cells (MSCs) have been shown to be capable of differentiating into osteoblasts, chondrocytes, adipocytes, myocytes, astrocytes and perhaps neurons. Recently, conditions have been developed where human MSCs can be expanded almost without limit in culture without apparently losing their multi-potentiality for differentiation. The cells appear to be potentially useful for the repair of extracellular matrix and the central nervous system.
Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system
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D. J. Prockop, S. A. Azizi, D. Colter, C. DiGirolamo, G. Kopen, D. G. Phinney; Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system. Biochem Soc Trans 1 August 2000; 28 (4): 341–345. doi: https://doi.org/10.1042/bst0280341
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