The origin and evolution of multicellular metazoa was accompanied by the appearance of extracellular matrix. The demineralized extracellular matrix of bone is enriched in morphogenetic proteins that induce bone. Bone morphogenetic proteins (BMPs) are intimately bound to collagens. BMP-4 has high affinity for type-IV collagen, and other binding proteins such as noggin and chordin. Soluble morphogens are kept in the solid state by extracellular matrix. In this sense Nature used the principles of affinity matrices long before humans patented the principle of affinity chromatography.
Conference Article| August 01 2000
Morphogenetic messages are in the extracellular matrix: biotechnology from bench to bedside
A. H. Reddi
A. H. Reddi 1
1Center for Tissue Regeneration and Repair and Department of Orthopaedic Surgery, University of California, Davis, Medical Center, Research Building 1, Room 2000, 4635 Second Avenue, Sacramento, CA 95817, U.S.A.
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A. H. Reddi; Morphogenetic messages are in the extracellular matrix: biotechnology from bench to bedside. Biochem Soc Trans 1 August 2000; 28 (4): 345–349. doi: https://doi.org/10.1042/bst0280345
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