Recent progress identifies targeted chromatin remodelling by co-repressor complexes as being an integral component of transcriptional silencing. Here we discuss how chromatin structure and the basal transcriptional machinery are manipulated by the co-repressor complex containing the Mi-2 nucleosomal ATPase, the histone-binding protein RbAp48 and histone deacetylase and by the co-repressor complex containing SIN3, RbAp48 and histone deacetylase. Remarkably, both of these complexes also contain methyl-CpG-binding proteins. This observation provides a molecular mechanism to integrate DNA methylation fully into gene control in vertebrates.
Conference Article| August 01 2000
Co-repressor complexes and remodelling chromatin for repression
A. P. Wolffe;
A. P. Wolffe 1
1Laboratory of Molecular Embryology, National Institute of Child Heath and Human Development, NIH, Building 18T, Room 106, Bethesda, MD 20892-5431, U.S.A.
1To whom correspondence should be addressed (e-mail email@example.com)
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F. D. Urnov;
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A. P. Wolffe, F. D. Urnov, D. Guschin; Co-repressor complexes and remodelling chromatin for repression. Biochem Soc Trans 1 August 2000; 28 (4): 379–386. doi: https://doi.org/10.1042/bst0280379
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