Steroids and related compounds are important in disease development and prevention, via steroid receptor-mediated and receptor-independent mechanisms. Interaction of endogenous oestrogens with the oestrogen receptor has unfortunate mitogenic effects in breast cancer. However, dietary consumption of non-steroidal weak oestrogens, such as the soy isoflavone phytoestrogens genistein and diadzein, is associated with a decreased breast cancer risk. This may arise in part from the suboptimal configuration induced in the transactivation helix of oestrogen receptor-β.
Conference Article| May 01 2001
New advances in the understanding of the role of steroids and steroid receptors in disease
H. Wiseman 1
1Department of Nutrition and Dietetics, Nutrition, Food and Health Research Centre. King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SEI 9NN, U.K.
1To whom correspondence should be addressed (e-mail firstname.lastname@example.org)
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H. Wiseman, R. Duffy; New advances in the understanding of the role of steroids and steroid receptors in disease. Biochem Soc Trans 1 May 2001; 29 (2): 205–209. doi: https://doi.org/10.1042/bst0290205
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