An immunosensing device, comprising a lipid membrane incorporating ion channels tethered to the surface of a gold electrode, has been reported [Cornell, Braach-Maksvytis, King, Osman, Raguse, Wieczorek and Pace (1997) Nature (London) 387, 580–583]. The present article describes key steps in the assembly of the device and provides further evidence for its proposed sensing mechanism.

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