Tumours are capable of activating blood coagulation through the expression of procoagulant molecules such as tissue factor, cancer procoagulant and hepsin. Initiation of the clotting cascade results in the generation of the activated serine proteases factor VIIa, factor Xa and thrombin. These proteases act via protease-activated receptors and tissue factor to alter gene expression, thereby modulating tumour cell growth, invasion, metastasis and angiogenesis.
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Conference Article| April 01 2002
Coagulation proteases and human cancer
M. T. Sampson;
M. T. Sampson 1
1Department of Surgical Oncology and Technology, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, U.K.
1To whom correspondence should be addressed (e-mail firstname.lastname@example.org).
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M. T. Sampson, A. K. Kakkar; Coagulation proteases and human cancer. Biochem Soc Trans 1 April 2002; 30 (2): 201–207. doi: https://doi.org/10.1042/bst0300201
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