Glucose 6-phosphate is an intermediate of pathways of glucose utilization and production as well as a regulator of enzyme activity and gene expression. Studies on the latter functions are in part based on measurement of the glucose 6-phosphate content in a whole-cell extract. Several studies have suggested that there are multiple subcellular pools of glucose 6-phosphate. It is proposed that this data can be interpreted in terms of channelling of metabolic intermediates through multiple pathways of glucose metabolism with leakage of glucose 6-phosphate from the channels into a single free pool. It is also proposed that measurement of total tissue content of glucose 6-phosphate approximates the free pool.
Conference Article| April 01 2002
Multiple glucose 6-phosphate pools or channelling of flux in diverse pathways?
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Loranne Agius, Josep Centelles, Marta Cascante; Multiple glucose 6-phosphate pools or channelling of flux in diverse pathways?. Biochem Soc Trans 1 April 2002; 30 (2): 38–43. doi: https://doi.org/10.1042/bst0300038
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