Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide, and we have little specific therapy to offer these patients. One potential strategy to limit loss of lung function in COPD would be to inhibit matrix-degrading proteinases. Several serine proteinases and matrix metalloproteinases are expressed in association with COPD in humans. Application of genetargeted macrophage elastase and neutrophil elastase to a mouse model of cigarette-smoke-induced emphysema has uncovered roles for these proteinases in airspace enlargement, and has identified many interactions between these proteolytic systems.
Conference Article| April 01 2002
Proteinases in chronic obstructive pulmonary disease
S. D. Shapiro
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S. D. Shapiro; Proteinases in chronic obstructive pulmonary disease. Biochem Soc Trans 1 April 2002; 30 (2): 98–102. doi: https://doi.org/10.1042/bst0300098
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