The biosynthesis of vitamin B12 is summarized, emphasizing the differences observed between the aerobic and anaerobic pathways. The biosynthetic route to adenosylcobalamin from its five-carbon precursor, 5-aminolaevulinic acid, can be divided into three sections: (1) the biosynthesis of uroporphyrinogen III from 5-aminolaevulinic acid, which is common to both pathways; (2) the conversion of uroporphyrinogen III into the ring-contracted, deacylated intermediate precorrin 6 or cobalt-precorrin 6, which includes the primary differences between the two pathways; and (3) the transformation of this intermediate to form adenosylcobalamin.
Conference Article| August 01 2002
Biosynthesis of cobalamin (vitamin B12)
A. I. Scott;
- Views Icon Views
- Share Icon Share
A. I. Scott, C. A. Roessner; Biosynthesis of cobalamin (vitamin B12). Biochem Soc Trans 1 August 2002; 30 (4): 613–620. doi: https://doi.org/10.1042/bst0300613
Download citation file: