Various biochemical and biophysical studies have demonstrated the existence of a novel iron-uptake mechanism in Pseudomonas aeruginosa, different from that generally described for ferrichrome and ferric-enterobactin in Escherichia coli. This new iron-uptake mechanism involves all the proteins generally reported to be involved in the uptake of ferric-siderophore complexes in Gram-negative bacteria (i.e. the outer membrane receptor, periplasmic binding protein and ATP-binding-cassette transporter), but differs in the behaviour of the siderophore. One of the key features of this process is the binding of iron-free pyoverdin to the outer membrane receptor FpvA in conditions of iron deficiency.
Conference Article| August 01 2002
A new mechanism for membrane iron transport in Pseudomonas aeruginosa
M. A. Abdallah;
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I.J. Schalk, M. A. Abdallah, F. Pattus; A new mechanism for membrane iron transport in Pseudomonas aeruginosa. Biochem Soc Trans 1 August 2002; 30 (4): 702–705. doi: https://doi.org/10.1042/bst0300702
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