Duodenal cytochrome b (Dcytb) is a haem protein similar to the cytochrome b561 protein family. Dcytb is highly expressed in duodenal brush-border membrane and is implicated in dietary iron absorption by reducing dietary ferric iron to the ferrous form for transport via Nramp2/DCT1 (divalent-cation transporter 1)/DMT1 (divalent metal-transporter 1). The protein is expressed in other tissues and may account for ferric reductase activity at other sites in the body.
Molecular evidence for the role of a ferric reductase in iron transport
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A. T. McKie, G. O. Latunde-Dada, S. Miret, J. A. McGregor, G. J. Anderson, C. D. Vulpe, J. M. Wrigglesworth, R. J. Simpson; Molecular evidence for the role of a ferric reductase in iron transport. Biochem Soc Trans 1 August 2002; 30 (4): 722–724. doi: https://doi.org/10.1042/bst0300722
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