The successful design of orally active non-toxic selective metal chelators is a much sought-after goal. In order to identify an ideal chelator for clinical use, a range of specifications must be considered, such as metal selectivity and affinity, kinetic stability of the complex, bioavailability and toxicity. In this overview the comparative properties of ligands capable of endowing complexes with such properties will be discussed.
Conference Article| August 01 2002
Design of therapeutic chelating agents
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R. C. Hider; Design of therapeutic chelating agents. Biochem Soc Trans 1 August 2002; 30 (4): 751–755. doi: https://doi.org/10.1042/bst0300751
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