During the past half century, we have progressed from simply viewing myo-inositol-containing glycerophospholipids as quantitatively minor membrane constituents to the present, very striking, situation in which more and more important cellular functions are being assigned to a plethora of phosphorylated derivatives of inositol and phosphatidylinositol. Two such examples are discussed briefly: the activation by environmental stresses of the single phosphoinositidase C of yeast, which is related to the phospholipase C δs of other eukaryotes, and the involvement of PtdIns(3,5)P2 in endomembrane trafficking.
Conference Article| February 01 2003
New insights into the roles of phosphoinositides and inositol polyphosphates in yeast
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R.H. Michell, N.M. Perera, S.K. Dove; New insights into the roles of phosphoinositides and inositol polyphosphates in yeast. Biochem Soc Trans 1 February 2003; 31 (1): 11–15. doi: https://doi.org/10.1042/bst0310011
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