Mammalian AMP-activated protein kinase presents strong structural and functional similarities with the yeast sucrose non-fermenting 1 (Snf1) kinase involved in the derepression of glucose-repressed genes. It is now clearly established that AMP-activated protein kinase in the liver decreases glycolytic/lipogenic gene expression as well as genes involved in hepatic glucose production. This is achieved through a decreased transcriptional efficiency of transcription factors such as sterol-regulatory-element-binding protein-1c, carbohydrate-response-element-binding protein, hepatocyte nuclear factor 4α or forkhead-related protein. Clearly, the long-term consequences of AMP-activated protein kinase activation have to be taken into account if activators of this enzyme are to be designed as anti-diabetic drugs.
Conference Article| February 01 2003
AMP-activated protein kinase and hepatic genes involved in glucose metabolism
Biochem Soc Trans (2003) 31 (1): 220–223.
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P. Ferré, D. Azzout-Marniche, F. Foufelle; AMP-activated protein kinase and hepatic genes involved in glucose metabolism. Biochem Soc Trans 1 February 2003; 31 (1): 220–223. doi: https://doi.org/10.1042/bst0310220
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