The genetic stability of living cells is continually threatened by endogenous reactive oxygen species and other genotoxic molecules. Of particular threat are the thousands of single-strand breaks that arise in each cell every day. If left unrepaired, such breaks can give rise to potentially clastogenic or lethal chromosomal double-strand breaks. This article summarizes our current understanding of how mammalian cells detect and repair single strand breaks, and provides insights into novel polypeptide components of this process.
Conference Article| February 01 2003
Protein–protein interactions during mammalian DNA single-strand break repair
Biochem Soc Trans (2003) 31 (1): 247–251.
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K.W. Caldecott; Protein–protein interactions during mammalian DNA single-strand break repair. Biochem Soc Trans 1 February 2003; 31 (1): 247–251. doi: https://doi.org/10.1042/bst0310247
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