To maintain genomic stability, despite constant exposure to agents that damage DNA, eukaryotic cells have developed elaborate and highly conserved pathways of DNA damage sensing, signalling and repair. In this review, we concentrate mainly on what we know about DNA damage sensing with particular reference to Lcd1p, a yeast protein that functions early in DNA damage signalling, and MDC1 (mediator of DNA damage checkpoint 1), a recently identified human protein that may be involved in recruiting the MRE11 complex to radiation-induced nuclear foci. We describe a model for the DNA damage response in which factors are recruited sequentially to sites of DNA damage to form complexes that can amplify the original signal and propagate it to the multitude of response pathways necessary for genome stability.
Conference Article| February 01 2003
The complex matter of DNA double-strand break detection
S.P. Jackson 1
*The Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge CB2 1QR, U.K.
†Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, U.K.
1To whom correspondence should be addressed at The Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge CB2 1QR, U.K. (e-mail firstname.lastname@example.org)
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Biochem Soc Trans (2003) 31 (1): 40–44.
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J.M. Bradbury, S.P. Jackson; The complex matter of DNA double-strand break detection. Biochem Soc Trans 1 February 2003; 31 (1): 40–44. doi: https://doi.org/10.1042/bst0310040
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