We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex pharmacological properties and how the conformation of the receptor modulates its ability to recruit co-regulators that are necessary for transcriptional activation.
Conference Article| February 01 2003
Structure and mechanism of the oestrogen receptor
Biochem Soc Trans (2003) 31 (1): 56–59.
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E.H. Kong, A.C.W. Pike, R.E. Hubbard; Structure and mechanism of the oestrogen receptor. Biochem Soc Trans 1 February 2003; 31 (1): 56–59. doi: https://doi.org/10.1042/bst0310056
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