This review summarizes the occurrence, properties and role in mucin O-glycosylation pathways of the various members of glycoprotein sulphotransferase families. Although a number of sulphotransferases have been cloned that act on mucin-type substrates in vitro, it is still difficult to determine exactly which enzymes are responsible for mucin sulphation in vivo. Sulphotransferases play a critical role in determining the chemical, physical and biological properties of mucins. Several of these enzymes have been shown to differ in expression and activity in cancer and inflammation.
Conference Article| April 01 2003
Sulphotransferases acting on mucin-type oligosaccharides
Biochem Soc Trans (2003) 31 (2): 318–325.
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I. Brockhausen; Sulphotransferases acting on mucin-type oligosaccharides. Biochem Soc Trans 1 April 2003; 31 (2): 318–325. doi: https://doi.org/10.1042/bst0310318
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