Molecular, biochemical and genetic characterization of ornithine decarboxylase, S-adenosylmethionine decarboxylase and spermidine synthase establishes that these polyamine-biosynthetic enzymes are essential for growth and survival of the agents that cause African sleeping sickness, Chagas' disease, leishmaniasis and malaria. These enzymes exhibit features that differ significantly between the parasites and the human host. Therefore it is conceivable that exploitation of such differences can lead to the design of new inhibitors that will selectively kill the parasites while exerting minimal, or at least tolerable, effects on the parasite-infected patient.
Conference Article| April 01 2003
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa
Biochem Soc Trans (2003) 31 (2): 415–419.
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O. Heby, S.C. Roberts, B. Ullman; Polyamine biosynthetic enzymes as drug targets in parasitic protozoa. Biochem Soc Trans 1 April 2003; 31 (2): 415–419. doi: https://doi.org/10.1042/bst0310415
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