The systemic inflammatory response syndrome (SIRS) is a major cause of morbidity and mortality, and is thought to be due to an over-amplification of an inflammatory response. The Toll-like receptor 4 (TLR4) Asp-299→Gly polymorphism has been shown to reduce lipopolysaccharide responsiveness. We examined whether this TLR4 polymorphism is associated with severity of SIRS. A trend was found between the minor allele and mortality in SIRS (odds ratio of 4.3; P=0.076), suggesting a role for TLR4 signalling in the severity of SIRS.
Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome
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N.J.A. Child, I.A. Yang, M.C.K. Pulletz, K. de Courcy-Golder, A.-L. Andrews, V.J. Pappachan, J.W. Holloway; Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome. Biochem Soc Trans 1 June 2003; 31 (3): 652–653. doi: https://doi.org/10.1042/bst0310652
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