Homologous recombination is a fundamental cellular process that rearranges genes both within and between chromosomes, promotes repair of damaged DNA and underpins replication. Much of our understanding of recombination stems from pioneering studies of bacterial and eukaryotic systems such as Escherichia coli and Saccharomyces cerevisiae. Since most archaeal species are extremophilic and difficult to cultivate, current knowledge of recombination in the Archaea is confined largely to comparative genomics and biochemistry. A clear view of what we can learn will not emerge until genetic and molecular systems have been established. We are developing such systems using Haloferax volcanii as a model organism, as it can be cultivated in the laboratory with ease and offers great potential for establishing tractable and informative genetic systems.
Skip Nav Destination
Conference Article| June 01 2003
Genetic analysis of homologous recombination in Archaea: Haloferax volcanii as a model organism
Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2003 Biochemical Society
Biochem Soc Trans (2003) 31 (3): 706–710.
T. Allers, H.-P. Ngo; Genetic analysis of homologous recombination in Archaea: Haloferax volcanii as a model organism. Biochem Soc Trans 1 June 2003; 31 (3): 706–710. doi: https://doi.org/10.1042/bst0310706
Download citation file:
Don't already have an account? Register
Get Access To This Article
Buy This Article