Clathrin-coated pits are the major ports of entry into the cell and are responsible for the internalization of a variety of biologically important macromolecules. These transport intermediates form as a result of the co-ordinated assembly of a number of cytosolic proteins on to the membrane which results in specific cargo recruitment. We have used a variety of approaches including permeabilized cell assays and light and electron microscopy to identify and characterize the proteins and enzymes involved in coated vesicle formation.
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Conference Article| June 01 2003
Clathrin-coated vesicle formation: a paradigm for coated-vesicle formation
E. Smythe 1
*Centre for Developmental Genetics, Department of Biomedical Sciences, University of Sheffield, Sheffield S10 2TN, U.K.
†Division of Immunology and Cell Biology, Wellcome Trust Biocentre, University of Dundee, Dundee, U.K.
1To whom correspondence should be addressed at the University of Sheffield (e-mail firstname.lastname@example.org).
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Biochem Soc Trans (2003) 31 (3): 736–739.
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E. Smythe; Clathrin-coated vesicle formation: a paradigm for coated-vesicle formation. Biochem Soc Trans 1 June 2003; 31 (3): 736–739. doi: https://doi.org/10.1042/bst0310736
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