PLUNC (palate, lung and nasal epithelium clone) is a small, secreted protein that is expressed in the oropharynx and upper airways of humans, mice and rats. We have described a family of at least 14 PLUNC genes localized on chromosome 20 (in humans), 2 (in mice) or 3 (in rats). These rapidly evolving proteins are structurally related to lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI). In the present analysis we comment on the comparative aspects of this protein family, which may function to protect epithelial surfaces from pathogenic micro-organisms.
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Conference Article| August 01 2003
Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families
C.D. Bingle 1
*Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2JF, U.K.
1To whom correspondence should be addressed (e-mail firstname.lastname@example.org).
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Biochem Soc Trans (2003) 31 (4): 806–809.
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C.D. Bingle, C.J. Craven; Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families. Biochem Soc Trans 1 August 2003; 31 (4): 806–809. doi: https://doi.org/10.1042/bst0310806
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