Postsynaptic clustering of GABAA (type A γ-aminobutyric acid) receptors is essential to ensure proper function of GABAergic synapses. This process is initiated during synapse formation and is maintained throughout life. The tubulin-associated protein gephyrin is required for clustering of GABAA receptors, but its specific role in this process is not understood. A second protein associated selectively with GABAA receptors at postsynaptic sites is dystrophin. It is present in a subset of GABAergic synapses along with several partners, forming the dystrophin-associated protein complex. In this review, we discuss recent advances in the role of neuronal activity and trans-synaptic signaling for the clustering of gephyrin and dystrophin during synaptogenesis and on the role of these proteins for plasticity and maintenance of mature synapses.
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August 01 2003
Pre- and post-synaptic mechanisms regulating the clustering of type A γ-aminobutyric acid receptors (GABAA receptors)
J.-M. Fritschy;
J.-M. Fritschy
1
*Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
1To whom correspondence should be addressed (e-mail [email protected]).
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C. Schweizer;
C. Schweizer
*Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
†Department of Biology and Department of Biochemistry & Molecular Biology, Penn State University, University Park, PA 16802, U.S.A.
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I. Brünig;
I. Brünig
2
*Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
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B. Lüscher
B. Lüscher
†Department of Biology and Department of Biochemistry & Molecular Biology, Penn State University, University Park, PA 16802, U.S.A.
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2003 Biochemical Society
2003
Biochem Soc Trans (2003) 31 (4): 889–892.
Citation
J.-M. Fritschy, C. Schweizer, I. Brünig, B. Lüscher; Pre- and post-synaptic mechanisms regulating the clustering of type A γ-aminobutyric acid receptors (GABAA receptors). Biochem Soc Trans 1 August 2003; 31 (4): 889–892. doi: https://doi.org/10.1042/bst0310889
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