The link between raised levels of LDL (low-density lipoprotein) cholesterol in the blood and atherosclerosis is incontrovertible. The situation with regard to TRLs (triacylglycerol-rich lipoproteins) is not as clear. Nevertheless, there is substantial evidence that TRLs may in some cases be just as atherogenic as triacylglycerol-poor LDL. This review focuses on three aspects of the link between TRLs and atherosclerosis: (i) the epidemiological evidence for an association between raised levels of TRLs and atherosclerosis, with particular reference to the results of the PROCAM study; (ii) the possible pathophysiological contribution of TRL to atherogenesis at the level of the arterial wall; and (iii) the case for specific lowering of triacylglycerol levels to prevent atherosclerosis.
Conference Article| October 01 2003
Triacylglycerol-rich lipoproteins and atherosclerosis – where is the link?
Biochem Soc Trans (2003) 31 (5): 1080-1084.
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P. Cullen; Triacylglycerol-rich lipoproteins and atherosclerosis – where is the link?. Biochem Soc Trans 1 October 2003; 31 (5): 1080–1084. doi: https://doi.org/10.1042/bst0311080
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