The mouse egg provided the first direct measurement of Ca2+ oscillations in any cell type. These sperm-induced Ca2+ oscillations occur at a relatively low frequency, and can be detected up to 18–20 h after sperm–egg fusion. The Ca2+ oscillations consist of two series of transients; the first lasts about 4 h, from metaphase II until interphase of the first cell cycle, and the second lasts the duration of the first mitotic division. This cell-cycle-regulated aspect to the pattern of Ca2+ signalling at fertilization is reflected in the role of the Ca2+ transients in stimulating exit from metaphase arrest. Recent developments have started to shed light on the mechanism initiating Ca2+ oscillations at fertilization, on how the frequency of the oscillations is set, and on what determines their temporal pattern.
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Conference Article| October 01 2003
Ca2+ oscillations at fertilization in mammals
Biochem Soc Trans (2003) 31 (5): 907–911.
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G. Halet, P. Marangos, G. FitzHarris, J. Carroll; Ca2+ oscillations at fertilization in mammals. Biochem Soc Trans 1 October 2003; 31 (5): 907–911. doi: https://doi.org/10.1042/bst0310907
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