We have investigated the effects of natriuretic peptides on oscillations in [Ca2+]c (cytosolic free Ca2+ concentration) in two different cell types: freshly isolated rat hepatocytes and the ECV304 cell line. Our data, from both cell types, suggest that natriuretic peptides modulate the frequency of [Ca2+]c oscillations through alterations in plasma membrane Ca2+ fluxes. Here, we review evidence for a role for plasma membrane Ca2+ fluxes in the control of the frequency of [Ca2+]c oscillations. We describe a hypothetical mechanism through which this might be achieved. We propose a physiological role for regulated control of Ca2+ efflux in modulating [Ca2+]c oscillations.

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