In this review we speculate that the anti-apoptotic protein Bcl-2 may regulate calcium signals involved in mediating cell death. Evidence that Ins(1,4,5)P3-mediated calcium release from the endoplasmic reticulum triggers apoptosis in response to diverse signals is summarized. Also, we review evidence that Bcl-2 regulates calcium release from the endoplasmic reticulum, and speculate that Bcl-2 may interact either functionally or physically with Ins(1,4,5)P3 receptors to modulate calcium signals that determine life or death decisions.
Conference Article| October 01 2003
Ins(1,4,5)P3-mediated calcium signals and apoptosis: is there a role for Bcl-2?
C.W. Distelhorst 1
*Departments of Medicine and Pharmacology, Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, U.S.A.
1To whom correspondence should be addressed, at Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106–4937, U.S.A. (e-mail firstname.lastname@example.org).
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Biochem Soc Trans (2003) 31 (5): 958–959.
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C.W. Distelhorst, H.L. Roderick; Ins(1,4,5)P3-mediated calcium signals and apoptosis: is there a role for Bcl-2?. Biochem Soc Trans 1 October 2003; 31 (5): 958–959. doi: https://doi.org/10.1042/bst0310958
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