The control of the intracellular localization of NCS (neuronal calcium sensor) proteins is of importance for their ability to respond appropriately to differing calcium signals. We examine the localization of three NCS proteins: NCS-1, KChIP-1 (potassium-channel-interacting protein 1) and hippocalcin. Additionally, the [Ca2+] dependency of the calcium-induced translocation of hippocalcin is investigated. The implications of the differential targeting of these proteins on calcium signal interpretation are considered.
Conference Article| October 01 2003
Role of myristoylation in the intracellular targeting of neuronal calcium sensor (NCS) proteins
Biochem Soc Trans (2003) 31 (5): 963–965.
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D.W. O'Callaghan, R.D. Burgoyne; Role of myristoylation in the intracellular targeting of neuronal calcium sensor (NCS) proteins. Biochem Soc Trans 1 October 2003; 31 (5): 963–965. doi: https://doi.org/10.1042/bst0310963
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