It is now clear that G-protein-coupled receptors can regulate programmed cell death (apoptosis) through a variety of mechanisms that are dependent on cell type and receptor subtype. Here we present evidence that the Gq/11-coupled subtypes of the muscarinic receptor family (namely M1, M3 and M5-muscarinic receptor subtypes) are able to protect against apoptotic cell death. In particular we demonstrate that the C-terminal tail of the M3-muscarinic receptor is an essential structural element for signalling to the anti-apoptotic pathway. Removal of the distal portion of the C-terminal tail results in a receptor that is coupled normally to the Gq/11/phospholipase C pathway and the mitogen-activated protein kinase pathway, but is unable to couple to the anti-apoptotic pathway. Furthermore, a poly-basic region conserved within the C-terminal tail of the Gq/11-coupled muscarinic receptor subtypes appears to be the structural determinant of coupling to the anti-apoptotic pathway.
Conference Article| December 01 2003
The anti-apoptotic response of the Gq/11-coupled muscarinic receptor family
Biochem Soc Trans (2003) 31 (6): 1182–1185.
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A.B. Tobin, D.C. Budd; The anti-apoptotic response of the Gq/11-coupled muscarinic receptor family. Biochem Soc Trans 1 December 2003; 31 (6): 1182–1185. doi: https://doi.org/10.1042/bst0311182
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