S1P (sphingosine 1-phosphate) is the ligand for a family of specific G-protein-coupled receptors that regulate a wide variety of important cellular functions, including vascular maturation, angiogenesis, cell growth, survival, cytoskeletal rearrangements and cell motility. However, S1P also may have intracellular functions. In this review, we discuss two examples that clearly indicate that intracellularly generated and exogenous S1P can regulate biological processes by divergent pathways.
Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways
- Views Icon Views
- Share Icon Share
S. Spiegel, S. Milstien; Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways. Biochem Soc Trans 1 December 2003; 31 (6): 1216–1219. doi: https://doi.org/10.1042/bst0311216
Download citation file: