Many proteins are translocated across or integrated into a cellular membrane without disrupting its integrity, although it is difficult to imagine how such macromolecular transmembrane movement can occur without simultaneously allowing significant small-molecule and ion diffusion across the bilayer. Recent studies have identified some molecular mechanisms that are involved in maintaining the permeability barrier of the endoplasmic reticulum membrane during co-translational protein translocation and integration. These mechanisms are both simple and direct in concept, but are operationally complex and require the co-ordinated and regulated interaction of several multicomponent complexes.
Conference Article| December 01 2003
Maintaining the permeability barrier during protein trafficking at the endoplasmic reticulum membrane
A.E. Johnson 1
Department of Medical Biochemistry and Genetics, Texas A&M University System Health Science Center, College Station, TX 77843-1114, U.S.A., Department of Chemistry, Texas A&M University, College Station, TX 77843, U.S.A., and Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, U.S.A.
1Address correspondence to College of Medicine, 116 Reynolds Medical Building, TAMUS HSC, 1114 TAMU, College Station, TX 77843-1114, U.S.A. (e-mail firstname.lastname@example.org).
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Biochem Soc Trans (2003) 31 (6): 1227–1231.
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A.E. Johnson; Maintaining the permeability barrier during protein trafficking at the endoplasmic reticulum membrane. Biochem Soc Trans 1 December 2003; 31 (6): 1227–1231. doi: https://doi.org/10.1042/bst0311227
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