Many of us recognize that some individuals seem ‘gifted’ in sporting ability. We may also have noted the association of such elite performance with past parental success, recognizing intuitively the role of inherited traits. With the expansion of molecular biology and associated technologies, we now find ourselves better able to explore these genetic influences. This article examines the role of the renin–angiotensin system in regulating physical performance, based on data arising from candidate gene-association studies. In particular, the association of angiotensin-converting enzyme genotype with performance-related phenotypes will be addressed. Finally, we will briefly discuss the applicability of this data to disease states such as heart failure.
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Conference Article| December 01 2003
The renin–angiotensin system and physical performance
H. Montgomery 1
Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, Rayne Building, 5 University Street, London WC1E 6JF, U.K.
1To whom correspondence should be addressed (e-mail email@example.com).
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Biochem Soc Trans (2003) 31 (6): 1286–1289.
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J. Payne, H. Montgomery; The renin–angiotensin system and physical performance. Biochem Soc Trans 1 December 2003; 31 (6): 1286–1289. doi: https://doi.org/10.1042/bst0311286
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