The eukaryotic cell-division cycle is regulated by three modules that control G1/S, G2/M and meta/anaphase transitions. By using mathematical modelling, we show the dynamic characteristics of these individual modules and we also assemble them together into a comprehensive model of the eukaryotic cell-division cycle. With this comprehensive model, we also discuss the mechanisms by which different checkpoint pathways stabilize different cell-cycle states and inhibit the transitions that drive cell-cycle progression.
Conference Article| December 01 2003
Modelling the controls of the eukaryotic cell cycle
B. Novák 1
*Molecular Network Dynamics Research Group of Hungarian Academy of Sciences and Budapest University of Technology and Economics, 1521 Budapest, Gellért tér 4, Hungary
†Collegium Budapest, Institute for Advanced Studies, 1014 Budapest, Szentháromság utca 2, Hungary
1To whom correspondence should be addressed, at Molecular Network Dynamics Group of Hungarian Academy of Sciences and Budapest University of Technology and Economics, 1521 Budapest, Gellért tér 4, Hungary (e-mail firstname.lastname@example.org).
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Biochem Soc Trans (2003) 31 (6): 1526-1529.
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B. Novák, J.J. Tyson; Modelling the controls of the eukaryotic cell cycle. Biochem Soc Trans 1 December 2003; 31 (6): 1526–1529. doi: https://doi.org/10.1042/bst0311526
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