Most of the triacylglycerol (TAG) utilized for the assembly of very-low-density lipoprotein (VLDL) in the secretory apparatus of the hepatocyte is mobilized by lipolysis of the cytosolic TAG pool, followed by re-esterification. The lipases involved include arylacetamide deacetylase and/or triacylglycerol hydrolase. Some of the re-esterified products of lipolysis gain access to an apolipoprotein-B-rich VLDL precursor to form mature VLDL. Some, however, are returned to the cytosolic pool in a process that is stimulated by insulin and inhibited by microsomal triacylglycerol transfer protein (MTP). Phospholipids also contribute to VLDL TAG in a process which involves ADP-ribosylation factor-1 (ARF-1)-mediated activation of phospholipase D. The temporary storage of TAG in the liver, followed by its mobilization and secretion as VLDL, form part of a process by which the liver protects vulnerable body tissues from excess lipotoxic non-esterified (‘free’) fatty acids in the plasma.
Conference Article| February 01 2004
Synthesis and function of hepatic very-low-density lipoprotein
G.F. Gibbons 1
Metabolic Research Laboratory, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, U.K.
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Biochem Soc Trans (2004) 32 (1): 59-64.
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G.F. Gibbons, D. Wiggins, A.-M. Brown, A.-M. Hebbachi; Synthesis and function of hepatic very-low-density lipoprotein. Biochem Soc Trans 1 February 2004; 32 (1): 59–64. doi: https://doi.org/10.1042/bst0320059
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