The determination and comparison of the structures of a number of glutamate dehydrogenases that span the spectrum of thermal stability from mesophiles to hyperthermophiles have revealed that the formation of extended ion-pair networks is a major stabilizing feature in the adaptation of the organism to life at 100°C. Analysis of the structures of other hyperthermophilic proteins has shown that ion-pair networks also play roles in their stabilization, including the phosphoglucose isomerase from Pyrococcus furiosus and the maltosyltransferase from Thermotoga maritima.
Conference Article| April 01 2004
From hyperthermophiles to psychrophiles: the structural basis of temperature stability of the amino acid dehydrogenases
Biochem Soc Trans (2004) 32 (2): 264-268.
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P.J. Baker; From hyperthermophiles to psychrophiles: the structural basis of temperature stability of the amino acid dehydrogenases. Biochem Soc Trans 1 April 2004; 32 (2): 264–268. doi: https://doi.org/10.1042/bst0320264
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