Macrophage apoptosis occurs within the granuloma, which is essential for successful immunity to tuberculosis. In vitro macrophage apoptosis is associated with the killing of intracellular Mycobacterium tuberculosis. A greater understanding of these observations will lead to new immunotherapies and improved vaccine design. The relevant apoptotic stimuli, the anti-mycobacterial mechanisms that they stimulate and their physiological relevance are reviewed in this paper.
Conference Article| June 01 2004
Macrophage apoptosis in host immunity to mycobacterial infections
Biochem Soc Trans (2004) 32 (3): 496-498.
- Views Icon Views
- Share Icon Share
- Cite Icon Cite
I.P. Fairbairn; Macrophage apoptosis in host immunity to mycobacterial infections. Biochem Soc Trans 1 June 2004; 32 (3): 496–498. doi: https://doi.org/10.1042/bst0320496
Download citation file: