Listeriolysin O, the major virulent determinant of Listeria monocytogenes, is known for forming pores on cholesterol-rich membranes. In the present study, we reveal its other facet, rafts clustering. By immunofluorescence microscopy, we show that the glycosylphosphatidylinositol-anchored proteins CD14 and CD24, which normally exhibit uniform distribution on J774 cells, undergo clustering upon treatment with LLO. The non-raft marker transferrin receptor is unaffected by such treatment. Rafts clustering might explain the induction of tyrosine phosphorylation observed on LLO-treated cells.
Conference Article| October 26 2004
Lipid rafts clustering and signalling by listeriolysin O
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N.O. Gekara, S. Weiss; Lipid rafts clustering and signalling by listeriolysin O. Biochem Soc Trans 1 November 2004; 32 (5): 712–714. doi: https://doi.org/10.1042/BST0320712
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