DNA methylation is one of several epigenetic mechanisms that play a regulatory role in genome programming and imprinting during embryogenesis. Aberrant DNA methylation has been implicated in the pathogenesis of a number of diseases associated with aging, including cancer and cardiovascular and neurological diseases. Evidence is accumulating that dietary factors in utero modulate disease risk in later life. Although folic acid is a key component of DNA methylation, the impact of folic acid availability in utero on DNA methylation patterns and disease risk in adulthood is at present poorly characterized. This review describes the relationship between folic acid and DNA methylation, and the association between DNA methylation during in utero development and aging.
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November 2004
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Conference Article|
October 26 2004
Folate and DNA methylation during in utero development and aging
J.A. McKay;
J.A. McKay
1
*Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle upon Tyne, NE1 7RU, U.K.
1To whom correspondence should be addressed (email [email protected]).
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E.A. Williams;
E.A. Williams
†Human Nutrition Unit, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, U.K.
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J.C. Mathers
J.C. Mathers
*Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle upon Tyne, NE1 7RU, U.K.
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Publisher: Portland Press Ltd
Received:
July 22 2004
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 The Biochemical Society
2004
Biochem Soc Trans (2004) 32 (6): 1006–1007.
Article history
Received:
July 22 2004
Citation
J.A. McKay, E.A. Williams, J.C. Mathers; Folate and DNA methylation during in utero development and aging. Biochem Soc Trans 1 November 2004; 32 (6): 1006–1007. doi: https://doi.org/10.1042/BST0321006
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