Stimulation with diverse agents activates the NF-κB (nuclear factor κB) transcription factor, affecting inflammatory and immune responses, proliferation, differentiation, apoptosis and tumourigenesis. Determining how NF-κB elicits such distinct responses is essential to understanding NF-κB function in diseased tissues. Recent developments illustrating that post-translational modification of NF-κB subunits influences their nuclear role are discussed. These observations suggest that diagnosis and new therapies based on reprogramming NF-κB activity could be more efficient than total NF-κB inhibition.
Conference Article| October 26 2004
Post-translational modification of RelA(p65) NF-κB
K.J. Campbell 1
1Division of Gene Regulation and Expression, School of Life Sciences, MSI/WTB Complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, U.K.
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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K.J. Campbell, N.D. Perkins; Post-translational modification of RelA(p65) NF-κB. Biochem Soc Trans 1 November 2004; 32 (6): 1087–1089. doi: https://doi.org/10.1042/BST0321087
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