HO-1 (haem oxygenase-1) is a stress-inducible enzyme that plays a protective role in inflammation. Pro-inflammatory mediators, including lipopolysaccharide and cytokines, induce HO-1 expression. The 5′-flanking region of the HO-1 gene contains binding sites for the transcription factors that regulate inflammation, including nuclear factor-κB and activator protein 1. However, these do not appear to mediate lipopolysaccharide-induced HO-1 gene expression. In response to haem and antioxidants, murine HO-1 is regulated by the transcription factor Nrf2 (NF-E2-related factor 2). This transcription factor may also be important in the regulation of HO-1 by pro-inflammatory stimuli.
Conference Article| October 26 2004
Haem oxygenase-1 in inflammation
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S.A. Rushworth, M.A. O'Connell; Haem oxygenase-1 in inflammation. Biochem Soc Trans 1 November 2004; 32 (6): 1093–1094. doi: https://doi.org/10.1042/BST0321093
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