Many cell types can generate thin actin-based protrusive structures, which are often classified under the general term of ‘filopodia’. However, a range of filopodia-like structures exists that differ both morphologically and functionally. In this brief review, we discuss the different types of filopodial structures, together with the actin-binding proteins and signalling pathways involved in their formation. Specifically, we highlight the differences between the filopodial extensions induced by the Rho GTPases Cdc42 and Rif.
Conference Article| October 26 2004
What is in a filopodium? Starfish versus hedgehogs
S. Passey 1
1Mammalian Cell Biology Laboratory, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, U.K.
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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S. Passey, S. Pellegrin, H. Mellor; What is in a filopodium? Starfish versus hedgehogs. Biochem Soc Trans 1 November 2004; 32 (6): 1115–1117. doi: https://doi.org/10.1042/BST0321115
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