Most protein-coding genes in eukaryotes are interrupted by non-coding intervening sequences (introns), which must be precisely removed from primary gene transcripts (pre-mRNAs) before translation of the message into protein. Intron removal by pre-mRNA splicing occurs in the nucleus and is catalysed by complex ribonucleoprotein machines called spliceosomes. These molecular machines consist of several small nuclear RNA molecules and their associated proteins [together termed snRNP (small nuclear ribonucleoprotein) particles], plus multiple accessory factors. Of particular interest are the U2, U5 and U6 snRNPs, which play crucial roles in the catalytic steps of splicing. In the present review, we summarize our current understanding of the role played by the protein components of the U5 snRNP in pre-mRNA splicing, which include some of the largest and most highly conserved nuclear proteins.
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November 2004
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Conference Article|
October 26 2004
Roles of the U5 snRNP in spliceosome dynamics and catalysis
I.A. Turner;
I.A. Turner
1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, U.K.
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C.M. Norman;
C.M. Norman
1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, U.K.
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M.J. Churcher;
M.J. Churcher
1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, U.K.
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A.J. Newman
A.J. Newman
1
1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, U.K.
1To whom correspondence should be addressed (email newman@mrc-lmb.cam.ac.uk).
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Publisher: Portland Press Ltd
Received:
June 23 2004
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 The Biochemical Society
2004
Biochem Soc Trans (2004) 32 (6): 928–931.
Article history
Received:
June 23 2004
Citation
I.A. Turner, C.M. Norman, M.J. Churcher, A.J. Newman; Roles of the U5 snRNP in spliceosome dynamics and catalysis. Biochem Soc Trans 1 November 2004; 32 (6): 928–931. doi: https://doi.org/10.1042/BST0320928
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