Regulation of protein synthesis is an important aspect of growth control. RNA polymerase (pol) III plays a key role in this process by catalysing production of tRNA and 5 S rRNA. Growth factors trigger a rapid increase in pol III activity and this is essential for cell proliferation. The transcription factor TFIIIB plays a key role in controlling pol III activity and is a target for regulation by a number of mechanisms. This review will focus on how TFIIIB is targeted by these proteins in response to mitogen stimulation.
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Conference Article| October 26 2004
Mitogenic stimulation of transcription by RNA polymerase III
E. Mauger ;
P.H. Scott 1
1Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, Davidson Building, University of Glasgow, Glasgow G12 8QQ, U.K.
1To whom correspondence should be addressed (email email@example.com).
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E. Mauger, P.H. Scott; Mitogenic stimulation of transcription by RNA polymerase III. Biochem Soc Trans 1 November 2004; 32 (6): 976–977. doi: https://doi.org/10.1042/BST0320976
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