The herpes simplex virus 1 ICP27 is an essential, highly conserved protein involved in various steps of herpes simplex virus 1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post-transcriptional level in inhibiting precursor mRNA splicing and in promoting nuclear export of viral transcripts. These activities are discussed.
The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expression
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R.W.P. Smith, P. Malik, J.B. Clements; The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expression. Biochem Soc Trans 1 June 2005; 33 (3): 499–501. doi: https://doi.org/10.1042/BST0330499
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