Complex I (NADH:ubiquinone oxidoreductase) is a membrane-bound, multisubunit enzyme. At present, there is no high-resolution structural model available for complex I and its mechanism of energy transduction is unknown. However, the subunit compositions of complex I from both eukaryotic and prokaryotic organisms have been determined, the sequences of their subunits are known and a coherent picture of the redox cofactors present in complex I has been developed. Here, I aim to describe and examine data relating to the mechanism of complex I and to build a framework to facilitate the discussion of possible conclusions and mechanistic models.
Conference Article| June 01 2005
Energy transduction by respiratory complex I – an evaluation of current knowledge
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J. Hirst; Energy transduction by respiratory complex I – an evaluation of current knowledge. Biochem Soc Trans 1 June 2005; 33 (3): 525–529. doi: https://doi.org/10.1042/BST0330525
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