The movement of drugs across biological membranes is mediated by two major classes of membrane transporters. Primary-active, ABC (ATP-binding cassette) multidrug transporters are dependent on ATP-binding/hydrolysis, whereas secondary-active multidrug transporters are coupled to the proton (or sodium)-motive force that exists across the plasma membrane. Recent work on LmrA, an ABC multidrug transporter in Lactococcus lactis, suggests that primary- and secondary-active multidrug transporters share functional and structural features. Some of these similarities and their implications for the mechanism of transport by ABC multidrug transporters will be discussed.
Similarities between ATP-dependent and ion-coupled multidrug transporters
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H. Venter, S. Shahi, L. Balakrishnan, S. Velamakanni, A. Bapna, B. Woebking, H.W. van Veen; Similarities between ATP-dependent and ion-coupled multidrug transporters. Biochem Soc Trans 26 October 2005; 33 (5): 1008–1011. doi: https://doi.org/10.1042/BST0331008
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